Do Magic Mushrooms cure Depression?


My friend Alfred in Amsterdam reports that after 10 month’s use, Magic Mushroooms have so far provided no “cure” as such for his debilitating and lifelong depression.

But his story is perhaps more nuanced and less hopeless than that bald statement may admit.

From a very early age, Alfred was aware that he was different – that something was wrong. Aged 10 he was described by his headmaster as “mercurial”. Up and down – like mercury. Nothing dramatic, not swings so severe that a doctor might diagnose him as bi-polar. None the less, in retrospect, Alfred recognizes that all was not entirely well in his childhood.

It was not until Alfred reached 30 that he began to realize something was very seriously amiss and that his condition might have a name.  There had been little in life that Alfred had truly enjoyed, and much that he vehemently did not enjoy. He later realized that he was anhedonic – or that at least his hedonic set point was low.  Certainly lower than those other children happily playing cricket on the school playing fields.

It is not that pleasure was entirely absent; just that mostly it was overshadowed by an angst for much (if not the most) of the time. Even at an early age, Alfred realized with a keen and puzzled awareness that his compatriots seemed to find more pleasure in life than he did.

After the age of 30 Alfred had to take his condition seriously. Such was his loathing of his job and his life he had a tendency to self medicate his misery with alcohol – not a wise policy.

With the “help” of much almost useless “talking therapy” Alfred began his search for answers and a cure. Were his parents to blame, did they provide a miserable or deprived childhood? He did not think this to have been the case. Was Yahweh of old testament fame alive and well after all, and torturing him for his badness and innate sinfulness? Was his condition endogenous, the result of a shitty hand in the cosmic genetic lottery?

Alfred looked high and low. He read. And he read, and he read. The Bible, and bible commentaries. Sacred literature from the East. Philosophy, psychology, psychiatry, science, mathematics. No one would ever have accused Alfred of being ill educated or ignorant but the depth of his erudition was dug in the years that followed.

And none of it made a blind bit of difference to his condition. Alfred long worked under the misguided assumption that a change in his external and physical circumstances would provide “The Answer”.

He shifted jobs, careers, continents. He lived here, there and everywhere doing this, that and the other.  He sought money – money was the root of all his problems. or rather its lack. If he were rich and secure he would not feel this hollowness inside, this rot from within.

And lo! Alfred did make some money. Enough to satisfy many of more modest ambition, but not Alfred of course. Enough for Alfred to leave the ghastly world of work and bosses and office drudgery.

But Alfred’s curse followed him even there, beyond the world of work and the hideous dull grind which it entails. Alfred was still miserable and the penny began to drop – his was a physiological problem; he was cursed by the cruel genetic lottery of life. The only cure possible would come from chemicals or a re-casting of his very DNA.

Over the course of many years, Alfred gave up alcohol and tried SSRIs. The abandonment of alcohol was undoubtedly a good choice on any number of grounds; as was his disavowal of nicotine.  The SSRIs? Pff….he became fat, his interest in the more physical aspects of relationships declined and he remained sad. Very, very sad.

So here he was, old, sad and embittered. A man who could describe himself as reasonably erudite and certainly a man who was acutely “aware”. Not a man who had failed to ponder on the meaning of life, but on the contrary one who had really never ceased (certainly in adulthood) to seek answers to the big questions of existence.

Poverty, cruelty and disease. Why did we have it? Could we not cure it? Behavior – why did we act so badly and did we not have the free will and maturity to mend our ways? Kindness and love, charity and altruism – surely these good men who preached such virtue over thousands of years can not all have been wrong? Even though Alfred came to believe that they were mere mortals after all and not scions of a supernatural deity.

So yes. Alfred could not describe himself as a “bad” person.  Or not intentionally and persistently bad anyway. Nor was he ignorant, stupid, unaware or unthinking. He was just miserable. And he came to realize that was no-one’s fault, least of all his own.  He simply lived in a world where everything was governed by pure chance. A lottery if you like.  And he had drawn a short straw.

Or perhaps Alfred lived in a world which was not governed by chance but by determinism. And from the very beginning it was therefor Alfred’s destiny to live a life of misery because he was little else but a collection of physical matter which would go its own way regardless of what Alfred did or did not do.

Over the years Alfred had tried many remedies for his cursed state. He was always on the look out. And then over the past couple of years he became aware of the brouhaha surrounding research into psychedelics.  Alfred devoured everything he could lay his hands on – nirvana beckoned. Surely it could not all be hype? Amongst the hyperbole and the over excited reports did there lie a grain of truth?

In short, Alfred acquired some magic mushrooms and gave it his best shot. For those who are not cognoscenti, the magic mushroom contains psilocybin. Taken in quantity the drug distorts reality – or some would say introduces an alternate reality.

Widespread literature (some from venerable medical institutions) reports that patients administered high doses of the drug experience the most spiritually important event of their lives.  They lose their ego, their self, but not their awareness. They become merged with the universe, the universal. They achieve bliss, they see their god. Or aliens or whatever they are culturally attuned to worship.  And for many months afterwards, a high percentage of such people feel content and happy. Well! What is not to like about that?

So did Alfred see god? Did he end up on the inside of an alien spaceship perhaps, chatting to infinitely wise beings far advanced from our crude and lowly status? Did Alfred enter nirvana, did he achieve bliss?

Well perhaps Alfred never went far enough; perhaps at the modest doses he contented himself with he got sniff of the godhead, a glimpse of nirvana.  But he never actually lost his ego; he never became subsumed in the consciousness of the universe.

More fool Alfred; try harder, do better, take more.

But what if anything did Alfred achieve by his efforts? His daring and culturally alien departure into the realms of the psychonaut. Fields Alfred believed to be inhabited by the louche, the unhinged, the unwashed, the lunatic.

He achieved perspective and some sense of resignation, acceptance of his lot. Under the influence of a modest dose he felt his thought patterns changing – it was an almost physical sensation. Stuff simply rearranged itself in his head.  He imagined he could feel new neuronal connections fizzing away, and rutted old paths of destructive thought patterns being dissolved. And his depression simply disappeared. Into the smoke, the ether. Alfred found himself incredulous that it had ever existed or that he had ever suffered from that cruel disease of the mind.

And Alfred did see things; both physically (in his mind’s eye) and metaphorically. He saw cascades of glorious Gothic arches, stained glass windows. He heard music as he had never witnessed it before- even if through his headphones rather than some from some ethereal and heavenly host. Oh and yes – he saw an alien spaceship – very clearly, and several times.  Sadly he was not invited inside, nor was he given audience by these wondrous beings.

And Alfred felt gnosis. He felt connected, un-alone. In a way he began to feel that sense of oneness with the universe so often reported by both mystics and pyschonauts alike.

Did it last, this feeling? Did the deep gloom which had cursed his life stay away? No, sadly it did not. A few days or a week later the black hounds of hell were snuffling angrily at his door, their paws scraping irritably, their jaws slavering in an unspoken demand to return back across the Styx.  A return to Stygian gloom.  At such moments Alfred felt deeply tired  – he faced the descent into hopelessness once again, as he had so often before. Was it worth continuing? Could he really ride this roller coaster any longer?

Alfred’s current view is that psilocybin provides welcome relief in his bleakest moments.  He has felt his mind change, his personality shift – permanently so. Yet not enough to defeat the cross he has borne for so many years.  He has become more patient, more resistant to the temptations of anger and conflict. He has achieved some lasting knowledge – a certainty that we see little of what is out there in our waking lives and that much could await us if we seek it out.

Alfred hopes that psilocybin may eventually rid him of his chains altogether, if he hangs on in there. He is optimistic even. But he is not there yet.



  1. Sometimes I wonder if chronic depression isn’t the result of being forced to live inside a monoculture body, inside a monoculture society eating monoculture crops from monoculture fields. So a shitty microbiome that is meant to be rich and wild in variety is instead overrun by the soy and corn versions of bacteria.

    It’s so unfair that some people have to endure chronic depression. My heart goes out to Alfred, and you, and my partner.

    Really cool at least that Alfred has had hints of some kind of at the very least respite. Hopefully it just takes longer than we’d hope for it to help him. Can hope, anyway. Would be awesome to have more than respite from that horrible burden.


    1. Thank you for those kind words Sue. It is odd that one day somebody can view an objective set of facts in one way and the next days those same facts appear, subjectively, to be entirely different. Such is life, such is uncaring Darwinian evolution; or so I must suppose. Yes, thank heavens Alfred discovered psilocybin – certainly better than nothing. I hope your partner may also be able to discover some solace, if not a cure, in the humble mushroom!


    2. I agree. There is early research demonstrating link between gut health and mental health. Alfred may want to go on a plant based, no alcohol/ sugar, low red meat, low carbs diet to see how it makes him feel. I recommend OurPath, an NHS approved, app based healthy eating programme. I am doing it now, the positive changes both physically and mentally are profound.


      1. I think poor old Alfred already lives on that sort of diet. Certainly no alcohol or nicotine. The psilocybin is certainly beneficial but perhaps not quite enough on its own.


  2. I’m sorry your friend has to deal with depression.

    Interestingly enough, I am a counseling student. And a classmate shared in class the other day that she suffered from anotexia nervosa all through her youth, was suicidal, terribly anxious and depressed, school issues. The whole thing. And after HS she still suffered. Trying to hold jobs ands such.

    She di research on her own about psychedelics Becuase she was so tired of all the nonsense she had to deal with. All the meds she was out on over the years. Not having a real solution for her.

    She researched psych. mushrooms (particularly Terrence McKenna). And one night she took 7g. 1/4 oz. by herself in her room. that’s a big dose btw. And it cured most of her issues. Her depression disappeared. For her, she said she was taken in a journey into herself and came to terms with who and what she was. That was 5 or so years ago.

    The “heroic” dose is what McKenna Advocates. A life transforming experience.

    I myself have no specifically therapeutic experience around psychedelics and psychotherapy

    But Just thought I’d share that. Hope your friend finds her way.


    1. I am very very grateful for your comments Lancek and thank you. While I did not bring that matter out too clearly in my retelling of Alfred’s tale I have for some time wondered whether a Terence McKenna heroic dose would have the desired effect. Yes I can entirely see that it would create a tabular rasa. I think Alfred would probably be best advised to try a heroic dose, although I imagine it would be best to do so under supervision.


  3. Psilocybin has been shown scientifically to be as or more effective as SSRIs at treating chronic depression, however for that Alfred would need to a) use a specific (high) dose and b) do it under supervision (in case of a bad trip) and c) in the right setting. There are multiple clinical trials running at the moment (MAPS site has a list), I d recommend he tried to do it this way. Well done to him for being open minded and trying plant medicines, hope he finds a way to cope whatever it is!


    1. I think his best chance may be a private sitter. He applied to Kings but it was double blind, placebo et. He is very mindful if the fact that the high dose is very much what has been used in clinical research. He was wondering whether paid for psychedilc therapy and a high dose trip under supervision in Amsterdam might be a route forward..??


      1. The UK Psychedelic society run retreats in the Netherlands. High dose, guides, integration afterwards. Under £1k. He will need to disclose that he has depression, not sure if they will be ok with it, they may modify the approach and he will need to go off SSRIs for a while beforehand.


      2. Hum…. Yes. He is a member and has been off SSRIs for some time. He decided to switch to shrooms. Alfred can be reasonably convincing so should be able to bluff his way through. Whether he should of course is another matter 🤣


      3. Good luck to him! It will be interesting to see what high dose will do. He may not have an easy trip. It may also not help.


      4. I very much enjoyed your video of your own experience. Sometimes it is probably good to let everything drop in a huge experience like that.


      5. Thanks Anthony. It was definitely a very powerful experience that still keeps giving a year later. If you watch a new Netflix special by British comedian Simon Amstell he talks about how ayahuasca cured his depression. Ayahuasca is scarier (more potent?) than mushrooms but your friend may want to try it. Blue Morph in Peru is a centre that is highly recommended. There is a documentary about its founder somewhere on Youtube. Alternatively a number of organisations in NL and Spain run aya retreats, minus the shaman.


  4. Has Alfred tried meditation? I guess he probably did if he read enough of the eastern spiritual stuff, but maybe not. Sometimes people read but don’t practise. I’ve done a bit of meditation and suffered from depression, although not as severely as Alfred, and it does seem to help. I have had long moments of bliss in meditation, and I think the brain learns that mode of operation more generally over time. Regular meditation, daily, for…well, a lifestyle change is the best. Thankfully, most of that is behind me, and I don’t meditate now, but I often think I’d be ever happier if I did. I know that when depression hits, it’s almost impossible to get out of it, but, from moments of relative contentment, if he has them at all, it’s possible to tune in to what a little bit of happiness feels like, and I think being happy can be little more than that, developing a new mental habit, really hard at first, but getting easier. And for me, a profound joy – and those feelings of connection, un-aloneness – emerged naturally out of the quiet stillness of meditation. Find peace, and it is happiness. I wish Alfred (and all beings) peace.


Leave a Reply to jjhiii24 Cancel reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s